Johns Hopkins University · Biomedical EngineeringOberdoerffer Lab
Philipp Oberdoerffer · Baltimore, Maryland
Research Focus
Dr. Philipp Oberdoerffer's lab at Johns Hopkins University focuses on understanding how epigenetic mechanisms influence DNA repair processes, particularly in the context of cancer. The team investigates how specific protein variants, especially a histone called macroH2A1, affect the repair of single-stranded DNA lesions that can lead to mutations and cancer. This research aims to improve our understanding of cancer vulnerabilities and potentially enhance treatment strategies.
DNA repairepigeneticscancermacroH2A1single-stranded DNA lesionsmutationtumorigenesisPARP inhibitorstopoisomerase inhibitors
Research Aims
3AIM 01Investigate the role of macroH2A1 isoforms in single-stranded DNA lesion repair.
AIM 02Determine the impact of macroH2A1 on genome integrity in relation to topoisomerase-induced DNA damage.
AIM 03Establish the function of macroH2A1 in cancer using mouse models and human tumor organoids.
Skills the Lab Values
cell culturegenomic approachesmouse modelsRNA sequencingWestern blotCRISPRreporter assaysbiochemical assaysalternative splicing analysis
Output against the department
Publications111bottom 21% of dept.466th of 595
this lab
most publishedleast published
Citations6.5kbottom 49% of dept.303rd of 595
this lab
most citedleast cited
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