University of Missouri-Columbia · BiochemistryAdeno-Associated Virus Research Laboratory
Michael S. Chapman · Columbia, Missouri
Research Focus
Dr. Michael Chapman's lab at the University of Missouri-Columbia focuses on improving gene therapy using adeno-associated viruses (AAV). They study how AAV interacts with host cells to better understand its entry process and develop more efficient gene delivery methods. Their research aims to design safer and more effective AAV vectors that can potentially treat various genetic diseases.
gene therapyAdeno-associated viruscell entryimmunotoxicitymolecular interactionsvirus-host interactionsvector efficiencystructural biology
Research Aims
5AIM 01Investigate the molecular interactions of AAV with host cell proteins.
AIM 02Determine the structures of key receptors involved in AAV entry.
AIM 03Assess factors affecting AAV neutralization by antibodies.
AIM 04Develop improved AAV vectors for safer gene therapy applications.
AIM 05Diversify computational methods to refine cryo-EM data for structural analysis.
Skills the Lab Values
cryogenic electron microscopy (cryo-EM)cryogenic electron tomography (cryo-ET)molecular modelingantibody characterizationgenetic engineeringprotein purificationcell culture techniquescomputational structural biology
Output against the department
Publications295top 22% of dept.88th of 402
this lab
most publishedleast published
Citations11ktop 45% of dept.180th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.