University of Connecticut · NeuroscienceImmune System and Neuropathology Unit
Stephen J Crocker · Storrs, Connecticut
Research Focus
Dr. Stephen J. Crocker's research focuses on understanding the immune system's role in globoid cell leukodystrophy (GLD), a severe genetic brain disorder. His lab investigates how CD8 T cells contribute to the disease's progression and pathology, utilizing mouse models and advanced genetic techniques. The aim is to uncover potential therapeutic targets to better manage or treat this devastating condition that currently lacks effective interventions.
globoid cell leukodystrophyCD8 T cellsneuroinflammationdemyelinationimmunitygenetic profilingmouse modelstransgenic animalsflow cytometrycellular pathology
Research Aims
3AIM 01Characterize the development of CD8 T cells in globoid cell leukodystrophy using knockout mouse lines.
AIM 02Evaluate the role of CD4 T cells in CD8 T cell-mediated immunity in GLD mice.
AIM 03Profile T cell responses to specific antigens and identify antigen-presenting cell types in the CNS.
Skills the Lab Values
flow cytometrysingle-cell RNA sequencingmouse modelstransgenic animal techniquesantibody administrationbiochemical assaysimmunological assaysdata analysisphenotypinghistology
Output against the department
Publications137bottom 48% of dept.347th of 671
this lab
most publishedleast published
Citations5.5kbottom 39% of dept.409th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.