University of California-Davis · PharmacologyYe Mechanotransduction Lab
Ye Chen-Izu · Davis, California
Research Focus
Dr. Ye Chen-Izu's lab at UC Davis focuses on understanding how mechanical forces affect the heart's function and its diseases. The lab investigates how heart muscle cells communicate with each other during contractions, particularly under stress from mechanical loading. By learning how these mechanisms work, the research aims to identify new treatments for heart conditions such as arrhythmias and heart failure, especially those triggered by high blood pressure.
mechanotransductioncardiomyocytesexcitation-contraction couplingheart diseasearrhythmiashypertensioncardiac functionmolecular mechanismsinnovative technologies
Research Aims
4AIM 01Investigate how mechanical load affects cardiomyocyte behavior.
AIM 02Elucidate molecular mechanisms of mechano-chemo-electro-transduction pathways.
AIM 03Study how load influences excitation-contraction coupling in cardiac cells.
AIM 04Explore the impact of mechanical stress on heart diseases like heart failure.
Skills the Lab Values
cell culturemechanical testingelectrophysiologymolecular cloningimmunofluorescence microscopyWestern blottingdata analysis using Pythontherapeutic discoverydynamic system modeling
Output against the department
Publications156bottom 44% of dept.259th of 462
this lab
most publishedleast published
Citations3.5kbottom 27% of dept.339th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.