SLUSaint Louis University · Biochemistry
Center for Blood Coagulation Research
Enrico Di Cera · Saint Louis, Missouri
Research Focus
Dr. Enrico Di Cera's lab at Saint Louis University focuses on understanding the structural biology of blood coagulation. They use advanced techniques like cryo-electron microscopy to study crucial proteins involved in hemostasis, such as prothrombin and factor V. By investigating how these proteins activate and interact, the lab aims to uncover new insights into blood coagulation processes that could have significant implications for therapies related to clotting disorders.
blood coagulationprothrombinthrombinfactor Vcryogenic electron microscopystructural biologyprotein dynamicsenzymology
Research Aims
4AIM 01Investigate the structural basis of prothrombin activation by prothrombinase.
AIM 02Characterize the interaction of thrombin with protein C during coagulation.
AIM 03Detail the structural mechanics of factor V activation in blood coagulation.
AIM 04Explore the conformational changes in coagulation proteins during activation.
Skills the Lab Values
cryogenic electron microscopystructural analysis of proteinsprotein purificationbioinformaticsdata visualizationkinetic modelingenzyme assayscomplex formation studies
Output against the department
Publications1bottom 1% of dept.402nd of 402
this lab
most publishedleast published
Citations0bottom 1% of dept.402nd of 402
this lab
most citedleast cited
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