Stanford University · GeneticsUrban Mosaicism Lab
Alexander Eckehart Urban · Stanford, California
Research Focus
Dr. Urban's lab at Stanford is focused on understanding the genetic variations that occur in individual cells within our bodies, a phenomenon known as somatic mosaicism. By developing and testing advanced techniques, the lab aims to accurately identify and characterize these genetic changes, which can have significant implications for understanding diseases and the biology of tissues. The work includes innovative methods to analyze the entire genome of single cells, which could lead to breakthroughs in personalized medicine.
somatic mosaicismgenome variationsingle cellsiPSClong-read sequencingstructural variantsbenchmarking methodsgenome analysistranscriptome analysis
Research Aims
5AIM 01Establish methods to identify and analyze somatic mutations in single human cells.
AIM 02Benchmark advanced sequencing techniques for accurate genome characterization.
AIM 03Develop high-throughput approaches for detecting structural variants in genomes.
AIM 04Enhance understanding of the relationship between mutations and cell phenotype.
AIM 05Create comprehensive resources for future research on genomic variation.
Skills the Lab Values
single cell analysisDNA amplification techniqueslong-read sequencingiPSC productionhigh-throughput sequencingbioinformaticsmolecular cloninggenomic DNA extractiontranscriptome profiling
Output against the department
Publications231top 37% of dept.96th of 259
this lab
most publishedleast published
Citations22ktop 25% of dept.64th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.