University of Missouri-Columbia · BiologyUterine Development and Health Lab
Thomas E Spencer · Columbia, Missouri
Research Focus
Dr. Thomas E. Spencer's lab at the University of Missouri-Columbia focuses on understanding the molecular and genetic factors that regulate the development of the uterus, particularly its glands which are crucial for successful pregnancies. The lab investigates how specific genes, particularly FOXA2, influence uterine health and play roles in infertility and uterine diseases. By employing advanced techniques in developmental biology and bioinformatics, the team aims to decipher the biological mechanisms behind uterine development and their implications for fertility and regenerative medicine.
uterine developmentinfertilityregenerative medicineFOXA2adenogenesisdevelopmental biologyepigeneticsgland morphogenesisbiological pathways
Research Aims
3AIM 01Define genetic and epigenetic pathways regulating uterine epithelial development.
AIM 02Investigate the role of FOXA2 in gland formation and function.
AIM 03Explore cellular pathways involved in adenogenesis in the uterus.
Skills the Lab Values
gene expression analysischromatin remodelingsingle-cell RNA sequencingmouse genetic modelsbioinformaticsorgan culture techniquesadvanced microscopystatistical analysis in Rexperimental designdata visualization
Output against the department
Publications575top 5% of dept.53rd of 1,033
this lab
most publishedleast published
Citations41ktop 7% of dept.70th of 1,033
this lab
most citedleast cited
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