University of Illinois Chicago · PhysiologyEndothelial Signaling and Vascular Health Lab
Monica Y Lee · Chicago, Illinois
Research Focus
Dr. Monica Y Lee's lab at the University of Illinois at Chicago focuses on understanding how endothelial cells, which line blood vessels, respond to blood flow and environmental cues. The lab investigates the role of a specific protein, nucleoporin93 (Nup93), in maintaining vascular health and preventing inflammation that can lead to atherosclerosis. Through their research, they aim to uncover new therapeutic approaches for cardiovascular diseases by exploring how Nup93 signaling affects endothelial function.
vascular healthendothelial cellsnuclear poresinflammationatherosclerosisAkt signalingcellular mechanicsgene expressionvascular biology
Research Aims
3AIM 01Identify how Nup93 affects Yap subcellular localization and activity in endothelial cells under laminar flow.
AIM 02Determine the role of Nup93 phosphorylation in mediating endothelial inflammation and barrier permeability.
AIM 03Investigate the impact of impaired Nup93 phosphorylation on atherosclerotic lesion formation in vivo.
Skills the Lab Values
cell culturemouse modelsmutant construct generationflow cytometryWestern blotimmunofluorescence microscopygene editingRNA isolationmolecular cloning
Output against the department
Publications10bottom 1% of dept.282nd of 286
this lab
most publishedleast published
Citations1.2kbottom 3% of dept.276th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.