University of Kentucky · PhysiologyAortopathy Research Lab
Alan Daugherty · Lexington, Kentucky
Research Focus
Dr. Alan Daugherty's lab at the University of Kentucky focuses on understanding diseases of the aorta, specifically aortopathies like aneurysms and dissections. The research aims to uncover the reasons behind differences in aortic function and structure, which can lead to potential new treatment options. By investigating cellular and molecular mechanisms, the lab hopes to develop targeted therapies for these life-threatening conditions.
aortopathyaneurysmaortic diseasesextracellular matrixsingle-cell RNA sequencing
Research Aims
3AIM 01Investigate structural and molecular mechanisms of aortic heterogeneity.
AIM 02Examine how cellular and extracellular variations contribute to aortopathies.
AIM 03Identify signaling pathways that affect aortic tissue characteristics.
Skills the Lab Values
mouse modelsultrasonographyMRIintravital microscopyproteomicshistologycell culturetranscriptomicsdata analysis
Output against the department
Publications577top 4% of dept.11th of 286
this lab
most publishedleast published
Citations28ktop 8% of dept.23rd of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.