University of Texas Southwestern Medical Center · Microbiology & ImmunologySalmonella Immunology Research Lab
Neal Mathew Alto · Dallas, Texas
Research Focus
Dr. Neal Mathew Alto's lab focuses on understanding how pathogenic bacteria, particularly Salmonella Typhimurium, evade the host's immune systems. They investigate the roles of specific bacterial proteins that coordinate the bacteria's division and survival within host cells. By studying these interactions, the lab aims to identify new strategies for developing drugs to combat infections caused by these bacteria.
Salmonellapathogenic bacteriavirulence factorshost-microbe interactionseffector proteins
Research Aims
3AIM 01Determine the roles of SPI-2 effector proteins in bacterial division within host cells.
AIM 02Investigate the interaction between bacterial effectors and host defense mechanisms.
AIM 03Test the theories of effector protein function using animal models of disease.
Skills the Lab Values
cell culturelive cell imagingsingle cell trackingmurine modelsmolecular cloning
Output against the department
Publications99bottom 34% of dept.317th of 486
this lab
most publishedleast published
Citations5.2kbottom 39% of dept.297th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.