University of North Carolina at Chapel Hill · NeuroscienceThe NeuroImaging Initiative
Yen-Yu Ian Shih · Chapel Hill, North Carolina
Research Focus
Dr. Yen-Yu Ian Shih's lab focuses on developing innovative imaging technologies to study brain function in mice. Specifically, they are working on a new fMRI technique called SORDINO, which aims to improve the sensitivity and specificity of imaging by tackling common issues found in traditional methods. Their research hopes to enhance our understanding of large-scale brain networks and has implications for public health by contributing new insights into brain-related disorders.
fMRIbrain imagingSORDINOrodent modelsneuroimagingawake imagingcontrast mechanismsMRI technologybehavioral neuroscience
Research Aims
4AIM 01Develop the SORDINO fMRI sequence and reconstruction software.
AIM 02Benchmark SORDINO performance against traditional fMRI methods.
AIM 03Investigate contrast mechanisms using invasive recordings during imaging.
AIM 04Enhance SORDINO sensitivity with manganese-enhanced MRI strategies.
Skills the Lab Values
functional MRIimage acquisitiondata reconstructionmouse modelsmagnetization transfer imagingcontrast-enhanced MRIneuroscience techniquesbehavioral assessments
Output against the department
Publications214top 34% of dept.230th of 671
this lab
most publishedleast published
Citations3.8kbottom 29% of dept.477th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.