University of Texas Southwestern Medical Center · BiochemistryPhillips Lab
Margaret A. Phillips · Dallas, Texas
Research Focus
Dr. Margaret A. Phillips leads a research lab focused on developing new drugs to combat malaria, particularly in light of increasing drug resistance. Her team aims to optimize DHODH inhibitors, which can target a specific enzyme crucial for the malaria parasite's survival, using both computational models and experimental techniques. The goal is to identify safer and more effective compounds that are less likely to lead to drug resistance, thus improving treatment options for this life-threatening disease.
malariaDHODH inhibitorsdrug resistancecomputational modelingenzyme inhibitors
Research Aims
3AIM 01Identify new generation DHODH inhibitors to combat drug-resistant malaria.
AIM 02Optimize pyrazole-based DHODH inhibitors focusing on potency and metabolic stability.
AIM 03Use experimental and computational approaches to understand the enzyme-ligand interactions and their resistance profiles.
Skills the Lab Values
lead optimizationcomputational chemistryin vitro testingstructural biologykinetics studies
Output against the department
Publications227top 34% of dept.135th of 402
this lab
most publishedleast published
Citations10ktop 47% of dept.190th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.