University of Alabama at Birmingham · Microbiology & ImmunologyThe Precision Oncology Lab
Masakazu Kamata · Birmingham, Alabama
Research Focus
Dr. Masakazu Kamata's lab focuses on developing advanced therapies for cancer treatment through innovative drug delivery systems. By engineering a special polymer called PMPC, they enhance the effectiveness of antibody-drug conjugates (ADCs), ensuring these drugs can target tumors more accurately and penetrate areas like the brain. This research aims to create safer, more efficient cancer treatments that can improve patient outcomes.
antibody-drug conjugatescancer therapydrug deliverypolymer engineeringimmunotherapycentral nervous systemmetastatic cancertherapeutic antibodies
Research Aims
5AIM 01Develop a polymer-based platform for targeted delivery of therapeutic antibodies.
AIM 02Enhance the efficacy of antibody-drug conjugates for cancer treatment.
AIM 03Test the delivery system in patient-derived xenograft mouse models.
AIM 04Engineer the PMPC polymer for better performance against therapy-resistant cancers.
AIM 05Explore the safety and effectiveness of new ADCs using modified polymers.
Skills the Lab Values
polymer synthesisin vivo modelsantibody engineeringanimal modelsimmunohistochemistrynanotechnology techniquesencapsulation methodsdrug dosage formulationcell culture
Output against the department
Publications88bottom 29% of dept.343rd of 486
this lab
most publishedleast published
Citations3.5kbottom 26% of dept.362nd of 486
this lab
most citedleast cited
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