MCWMedical College of Wisconsin · Biophysics
Laboratory of Antibiotic Discovery and Structural Biology
Candice S Klug · Milwaukee, Wisconsin
Research Focus
Dr. Candice S. Klug's lab focuses on understanding essential bacterial proteins to develop novel antibiotics against drug-resistant bacteria such as E. coli and Enterococcus faecalis. By integrating biophysical and microbiological methods with advanced electron paramagnetic resonance (EPR) spectroscopy, her research aims to provide crucial insights into protein structure and dynamics, paving the way for innovative therapeutic strategies. The lab's work not only addresses antibiotic resistance but also advances biomedical technologies for diverse applications in human health.
bacterial proteinsantibiotic resistanceEPR spectroscopystructural biologydrug designGram-negative bacteriaEnterococcus faecalisGram-positive bacteriabiophysical methodsnovel antibiotics
Research Aims
5AIM 01Investigate the structure and dynamics of essential bacterial proteins.
AIM 02Develop novel antibiotics targeting Gram-negative bacteria.
AIM 03Enhance EPR spectroscopy technologies for biomedical applications.
AIM 04Explore drug-resistant mechanisms in Enterococcus faecalis.
AIM 05Utilize biophysical methods for rational drug design.
Skills the Lab Values
EPR spectroscopyprotein purificationcell culturebiophysical assaysstructural analysiscomputational modelingantibiotic susceptibility testingmicrobiological techniquesdata interpretationdrug discovery methods
Output against the department
Publications112bottom 40% of dept.6th of 10
this lab
most publishedleast published
Citations2.9kbottom 20% of dept.8th of 10
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.