University of Pennsylvania · Biomedical EngineeringRadhakrishnan Exosomes Lab
Ravi Radhakrishnan · Philadelphia, Pennsylvania
Research Focus
Dr. Ravi Radhakrishnan's lab at the University of Pennsylvania investigates how cancer cells communicate with their environment to promote the spread of tumors, especially in aggressive types like triple-negative breast cancer. The research focuses on small vesicles called exosomes that cancer cells use to suppress the immune system and help tumors grow and spread in the body. By studying the physical properties of the tumor environment, such as stiffness, the lab aims to uncover new ways to combat cancer progression and enhance the effectiveness of cancer immunotherapies.
exosomesmetastasistriple-negative breast cancerimmune systemextracellular matrixtumor microenvironmentbiomedical engineeringmechanobiologyimmunotherapyliquid biopsy
Research Aims
3AIM 01Investigate how tissue tension affects exosome production in triple-negative breast cancer cells.
AIM 02Explore the role of exosomes in promoting metastatic progression in mice models.
AIM 03Examine how tumor-derived exosomes can suppress the immune response against cancer.
Skills the Lab Values
cell culturegenetically engineered mouse modelsin vivo imagingimmunohistochemistryWestern blottingflow cytometryRNA extraction and analysismicroscopybiostatisticscomputational modeling
Output against the department
Publications275top 35% of dept.207th of 595
this lab
most publishedleast published
Citations12ktop 29% of dept.171st of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.