University of Iowa · Microbiology & ImmunologyHerpesvirus Assembly Research Group
Richard J Roller · Iowa City, Iowa
Research Focus
Dr. Richard J Roller's lab at the University of Iowa focuses on understanding how herpesviruses assemble by examining the interactions between viral proteins. By using innovative techniques such as directed evolution and chimeric viruses, the lab aims to discover critical protein interactions that are essential for viral assembly and could lead to improved viral therapies and vaccines.
herpesvirusviral assemblychimeric virusesdirected evolutionviral interactionsvaccine developmentproteomics
Research Aims
5AIM 01Identify critical interactions between herpesvirus proteins involved in assembly.
AIM 02Characterize the mechanisms of action of essential viral protein interactions.
AIM 03Apply directed evolution to study viral assembly functions.
AIM 04Map mutations that confer functional advantages in viral growth.
AIM 05Develop novel strategies for targeting herpesvirus assembly in therapeutic applications.
Skills the Lab Values
cell culture techniquesviral protein analysisdirected molecular evolutionchimeric virus constructionproteomic analysismutation mappinggene targetingbiological assays
Output against the department
Publications81bottom 27% of dept.354th of 486
this lab
most publishedleast published
Citations4.5kbottom 35% of dept.314th of 486
this lab
most citedleast cited
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