University of Minnesota-Twin Cities · Microbiology & Immunology · BiologySkinner Lab
Pamela J Skinner · Minneapolis, Minnesota
Research Focus
Dr. Pamela J Skinner's lab focuses on understanding how HIV persists in the body, particularly in secretive reservoirs like the gut and brain. They are developing innovative therapies that use genetically engineered immune cells to seek out and eliminate these hidden viral reservoirs, aiming for a potential cure for HIV. This research is crucial for improving treatment strategies and possibly eradicating the virus in infected individuals.
HIVCAR T cellsviral reservoirsCNSgut microbiomeimmunotherapySIVT cell therapy
Research Aims
5AIM 01Investigate the role of myeloid cells in HIV persistence in the CNS
AIM 02Develop CAR T cell therapies targeting gut and CNS reservoirs of HIV
AIM 03Assess the effectiveness of engineered T cells in clearing viral reservoirs
AIM 04Determine cell localization and persistence of CAR T cells in infected tissue
AIM 05Evaluate treatment strategies for durable HIV remission.
Skills the Lab Values
cell culturein vivo animal modelsRNA analysisflow cytometrygenetic engineeringimmunophenotypingviral load assaysB cell assays
Output against the department
Publications94bottom 32% of dept.1,025th of 1,518
this lab
most publishedleast published
Citations5.1kbottom 38% of dept.935th of 1,518
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.