Duke University · Microbiology & ImmunologyThe Antibody Nexus
Jose R Conejo-Garcia · Durham, North Carolina
Research Focus
Dr. Conejo-Garcia's lab focuses on developing innovative immunotherapies for cancer treatment. They engineer specialized antibodies that can penetrate tumor cells, targeting specific mutated proteins responsible for cancer growth. The goal is to enhance the effectiveness of immunotherapies and help patients whose tumors are resistant to current treatments.
immunotherapytumor cell-penetrating antibodiesoncogenic mutationscancer resistanceKRASantibody engineeringT cell immunitytranscytosisclinical translation
Research Aims
3AIM 01Elucidate the mechanisms of PIGR-binding IgGs in neutralizing tumor mutations.
AIM 02Define how PIGR-binding IgG affects T cell-dependent anti-tumor immunity.
AIM 03Determine the effectiveness of tumor cell-penetrating antibodies against resistant mutations in human cancers.
Skills the Lab Values
antibody engineeringcell culturecancer cell line assaysflow cytometryprotein purificationmicroscopyWestern blotPCRanimal modelsimmunological assays
Output against the department
Publications829top 1% of dept.7th of 486
this lab
most publishedleast published
Citations28ktop 11% of dept.55th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.