Indiana University-Purdue University-Indianapolis · Microbiology & ImmunologyThe Immune Echo Lab
Randy R Brutkiewicz · Indianapolis, Indiana
Research Focus
Dr. Randy Brutkiewicz's lab at Indiana University Indianapolis focuses on understanding how the immune system, specifically a type of immune cell called MAIT cells, contributes to Alzheimer's disease (AD) and its associated neuroinflammation. By investigating the mechanisms by which these cells and their interactions with brain cells like microglia and astrocytes impact AD pathology, the lab aims to uncover new therapeutic targets for this devastating disease.
Alzheimer's DiseaseneuroinflammationMAIT cellsmicrogliaIL-17A
Research Aims
3AIM 01Determine the importance of brain microglial and astrocyte MR1 in Alzheimer's pathology.
AIM 02Define the contribution of IL-17A in MR1/MAIT cell-dependent Alzheimer's disease development.
AIM 03Determine the impact of MAIT cell numbers in Alzheimer's neuroimmunopathology.
Skills the Lab Values
cell cultureflow cytometrymouse modelsimmunohistochemistrymolecular biology techniques
Output against the department
Publications183top 36% of dept.175th of 486
this lab
most publishedleast published
Citations6.3kbottom 46% of dept.262nd of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.