University of Southern California · PharmacologyProtein Aggregation Research Lab
Paul Matthew Seidler · Los Angeles, California
Research Focus
The lab led by Paul Matthew Seidler at USC focuses on understanding how proteins aggregate and how certain molecules, known as disaggregases, can control this process. By studying how proteins can be both catalyzed to aggregate and disaggregated back to their functional forms, the lab aims to uncover new ways to address diseases related to protein misfolding. Their research could lead to better diagnostics and therapies for these serious conditions.
protein aggregationdisaggregasesprotein misfoldingchaperonesproteasomesbioinformaticsbiochemical analysismolecular mechanismsdisease diagnostics
Research Aims
5AIM 01Investigate the role of disaggregases in protein aggregation and disaggregation.
AIM 02Identify new biological disaggregases in the human metabolome.
AIM 03Explore the molecular mechanisms that underlie protein aggregation diseases.
AIM 04Determine the conditions under which disaggregases toggle protein activity.
AIM 05Develop diagnostics and therapeutics aimed at protein misfolding diseases.
Skills the Lab Values
protein purificationcell culture techniquesbiochemical assaysbioinformatics analysisWestern blottingmicroscopyflow cytometrydata visualization in Pythonmetabolomics
Output against the department
Publications55bottom 8% of dept.421st of 462
this lab
most publishedleast published
Citations2.2kbottom 15% of dept.392nd of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.