Case Western Reserve University · PhysiologyEph Signaling and Neurovascular Research Lab
Matthias Buck · Cleveland, Ohio
Research Focus
Dr. Matthias Buck's lab at Case Western Reserve University focuses on the role of Eph receptors in cell signaling related to blood vessel formation and neurological diseases like Alzheimer's. His research aims to uncover the molecular mechanisms behind Eph receptor interactions, particularly how these proteins affect the integrity of the blood-brain barrier. This work is significant because understanding these mechanisms can contribute to developing new diagnostic tools and therapies for neurodegenerative and vascular diseases.
Eph receptorsblood-brain barrierAlzheimer's diseasecell signalingneurodegenerationmolecular interactionscancer metastasisdiagnostic developmenttherapeutic agents
Research Aims
5AIM 01Identify key residues important for Eph domain interactions.
AIM 02Characterize the interactions of Eph receptors with cellular membranes.
AIM 03Investigate the structural differences in Eph receptors related to kinase activity.
AIM 04Understand the role of Eph receptors in blood-brain barrier dysfunction.
AIM 05Develop insights for the creation of diagnostic and therapeutic agents.
Skills the Lab Values
X-Ray Crystallographymolecular cloningprotein expressionprotein purificationWestern blottingcell culture techniquesfluorescence microscopybiochemical assaysmutagenesisbioinformatics
Output against the department
Publications341top 13% of dept.36th of 286
this lab
most publishedleast published
Citations7.3ktop 45% of dept.130th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.