Washington University in St Louis · Microbiology & ImmunologySibley Lab
L. David Sibley · Saint Louis, Missouri
Research Focus
Dr. L. David Sibley's lab at Washington University focuses on understanding and combating chronic infections caused by the parasites Toxoplasma gondii and Cryptosporidium. The research primarily aims to develop new drug therapies that can effectively treat chronic stages of these infections, which pose significant health risks, particularly to immunocompromised individuals. By exploring genetic factors, microbial interactions, and developing novel inhibitors, the lab is working toward innovative solutions for these pressing public health issues.
Toxoplasma gondiiCryptosporidiumchronic infectiondrug developmentmicrobial metabolites
Research Aims
5AIM 01Identify new compounds that effectively eliminate chronic Toxoplasma gondii infections.
AIM 02Investigate the genetic basis of Cryptosporidium host infectivity.
AIM 03Explore the role of microbial metabolites on parasite biology.
AIM 04Develop inhibitors for TgCDPK1 to combat chronic toxoplasmosis.
AIM 05Map genetic factors that influence virulence and pathogenicity in Cryptosporidium.
Skills the Lab Values
cell cultureanimal modelsPCRCRISPR/Cas9 gene editingin vitro assaysbioinformaticsflow cytometryADME-Tox analysis
Output against the department
Publications385top 9% of dept.46th of 486
this lab
most publishedleast published
Citations39ktop 6% of dept.28th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.