Columbia University in the City of New York · BiologyNeurodegeneration Protein Dynamics Lab
Natura Myeku · New York, New York
Research Focus
Dr. Natura Myeku's lab at Columbia University Health Sciences investigates how specific proteins degrade in neurodegenerative diseases like Alzheimer's. The research focuses on understanding the roles of specialized proteins called immunoproteasomes, especially during inflammation, and how their dysfunction might contribute to disease progression. The lab combines advanced techniques to unravel the mechanisms behind protein accumulation that characterizes diseases of aging.
immunoproteasomeAlzheimer's Diseaseneurodegenerative diseasesprotein degradationmulti-omics
Research Aims
3AIM 01Investigate the role of immunoproteasomes in Alzheimer's disease progression.
AIM 02Understand the impact of immunoproteasome deficiencies on protein accumulation.
AIM 03Elucidate the shared mechanisms of failed protein breakdown in neurodegenerative diseases.
Skills the Lab Values
RNA sequencingmass spectrometrymouse modelscell culturebiochemical assays
Output against the department
Publications23bottom 3% of dept.1,006th of 1,033
this lab
most publishedleast published
Citations1.4kbottom 9% of dept.945th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.