UGUniversity of Georgia · Physiology
Microglial Response Laboratory
Jason R Richardson · Athens, Georgia
Research Focus
Dr. Jason R. Richardson's lab at the University of Georgia focuses on understanding how microglial cells, which are the brain's immune defenders, contribute to neuroinflammation and diseases like Parkinson's. The lab is particularly interested in a specific proton channel called Hv1 and how its activity influences the brain's response to toxic substances like paraquat, a common herbicide. By delving into the mechanisms behind these processes, the goal is to discover new therapeutic strategies that could help slow down or prevent neurodegenerative diseases.
neuroinflammationmicrogliaParkinson's diseaseparaquatNLRP3 inflammasomeproton channelneurodegenerationtoxicant exposurereactive oxygen species
Research Aims
3AIM 01Determine mechanisms of Hv1 regulation following paraquat exposure.
AIM 02Define the role of Hv1 in regulating the NLRP3 inflammasome following paraquat exposure.
AIM 03Analyze the contribution of microglial Hv1 and the NLRP3 inflammasome in neurodegeneration after paraquat exposure.
Skills the Lab Values
cell cultureanimal modelsWestern blotPCRelectrophysiologyin vivo studieschromatin immunoprecipitationpatch clampimmunohistochemistry
Output against the department
Publications232top 25% of dept.70th of 286
this lab
most publishedleast published
Citations11ktop 30% of dept.86th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.