University of North Carolina at Chapel Hill · PharmacologyHahn Lab
Klaus M. Hahn · Chapel Hill, North Carolina
Research Focus
Dr. Klaus M. Hahn's lab focuses on understanding how cells communicate and behave by developing advanced imaging techniques to visualize and control protein activity in real time. They study the dynamics of signaling in various contexts, like immune cells and cancer progression, to uncover fundamental principles of cell biology. The aim is to create tools that can help researchers explore diverse biological questions, especially related to how cells react to their environment.
protein signalingmicroscopybiosensorscell behaviorcancer metastasisimmunologycytoskeletal dynamicsquantitative imaging
Research Aims
5AIM 01Develop novel imaging techniques to visualize protein activity.
AIM 02Create biosensors to study molecular conformational changes in living cells.
AIM 03Investigate cell behavior during frustrated phagocytosis in macrophages.
AIM 04Explore how cancer cells navigate mechanical environments to reach blood vessels.
AIM 05Examine the interplay of chemical gradients and mechanical forces on cell dynamics.
Skills the Lab Values
microscopybiosensor developmentimage analysismolecular biology techniquesmathematical modelingcell cultureprotein engineeringsignal transduction studies
Output against the department
Publications612top 6% of dept.30th of 462
this lab
most publishedleast published
Citations26ktop 12% of dept.55th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.