Stanford University · GeneticsLi Immunology Lab
Jin Billy Li · Stanford, California
Research Focus
The lab focuses on understanding how RNA editing impacts the immune system, specifically in regulating the body's response to infections while avoiding attacks on its own cells. By studying an enzyme called ADAR1, the lab aims to uncover how this enzyme edits RNA to prevent autoimmune diseases and enhance our understanding of related inflammatory conditions. This work combines genetic screening and biochemical methods to identify how specific RNA molecules are processed within cells, paving the way for new therapeutic approaches.
RNA editingimmunogenic dsRNAsinnate immunityADAR1autoimmune diseasesMDA5double-stranded RNAgene expressioninflammatory diseases
Research Aims
5AIM 01Investigate how ADAR1 interacts with innate immune pathways.
AIM 02Identify specific dsRNAs that require ADAR1 editing to avoid autoimmune responses.
AIM 03Develop methods to characterize the immunogenicity of dsRNAs in inflammatory diseases.
AIM 04Utilize genetic and biochemical techniques to explore the regulatory mechanisms of RNA editing.
AIM 05Create predictive models to assess immunogenic dsRNA burdens in patients with autoimmune diseases.
Skills the Lab Values
genetic screeningbiochemical assaysmouse modelsRNA sequencingcell culturecomputational modelingdata analysisimmunofluorescencemolecular cloning
Output against the department
Publications122bottom 39% of dept.159th of 259
this lab
most publishedleast published
Citations24ktop 23% of dept.59th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.