Johns Hopkins University · PhysiologyLaboratory of Histone Modification and Cancer
Cynthia Wolberger · Baltimore, Maryland
Research Focus
Dr. Cynthia Wolberger's lab at Johns Hopkins University focuses on understanding how specific chemical modifications to histone proteins, which are crucial for packaging DNA, regulate gene expression and DNA repair. The team employs advanced techniques to investigate the role of ubiquitin attachment to histones in the context of cancer, aiming to develop new therapies targeting these pathways. Their work is not only fundamental to our understanding of gene regulation but also has the potential to lead to innovative treatments for difficult-to-treat cancers.
chromatin modificationhistone ubiquitinationDNA repairgene expression regulationcancer therapeutics
Research Aims
5AIM 01Investigate the mechanism of ubiquitin attachment to histone H2B during transcription.
AIM 02Explore how histone modifications interact to regulate gene activation.
AIM 03Develop inhibitors targeting deubiquitinating enzymes for cancer treatment.
AIM 04Determine the role of histone ubiquitination in promoting cell proliferation in leukemia.
AIM 05Uncover molecular insights that can lead to novel cancer therapies.
Skills the Lab Values
cryogenic electron microscopyX-ray crystallographybiochemistry techniquescell culturedrug designgene expression assays
Output against the department
Publications244top 23% of dept.65th of 286
this lab
most publishedleast published
Citations17ktop 17% of dept.49th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.