University of Minnesota-Twin Cities · BiochemistryCalcium Regulation and Drug Discovery Lab
David D Thomas · Minneapolis, Minnesota
Research Focus
David D. Thomas's lab at the University of Minnesota focuses on developing new drugs to treat skeletal muscle disorders by targeting the regulation of calcium within muscle cells. The team uses innovative fluorescent biosensors to identify small molecules that can correct dysfunctional calcium channels and pumps in muscle tissue. Their research aims to improve therapies for myopathies and other related diseases.
skeletal musclecalcium regulationdrug discoveryfluorescent biosensorsFRETmyopathyprotein dynamicsin vitro screeninghigh-throughput screening
Research Aims
5AIM 01Develop small-molecule drugs for skeletal muscle disorders related to calcium dysregulation.
AIM 02Create fluorescent biosensors to study protein structural dynamics in sarcoplasmic reticulum.
AIM 03Identify drug candidates that reduce RyR1 calcium leaks in muscle fibers.
AIM 04Enhance SERCA1a activity to restore normal calcium transport in muscle cells.
AIM 05Collaborate with experts to leverage various disciplines in drug discovery.
Skills the Lab Values
fluorescence resonance energy transfer (FRET)high-throughput screeningcell culturemouse modelsprotein engineeringfluorescent biosensor designdrug screening assaysin vivo muscle assaysbiochemical assays
Output against the department
Publications799top 3% of dept.14th of 402
this lab
most publishedleast published
Citations19ktop 23% of dept.91st of 402
this lab
most citedleast cited
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