Augusta University · BiologyThe Diabetic Renal Research Lab
Jian-Kang Chen · Augusta, Georgia
Research Focus
Dr. Jian-Kang Chen's research lab focuses on understanding how diabetes affects kidney function, particularly how it increases the risk of acute kidney injury (AKI). The lab investigates the cellular and molecular changes that lead to kidney hypertrophy and susceptibility to damage in diabetic patients. Their work aims to find new therapeutic targets for preventing kidney damage in these patients, ultimately improving health outcomes for those with diabetes-related kidney issues.
acute kidney injurydiabetesrenal hypertrophyER stressautophagymTORC1chronic kidney diseasecell death
Research Aims
4AIM 01Investigate the molecular changes that lead to renal hypertrophy in diabetic kidneys.
AIM 02Determine how hypertrophy contributes to AKI risk in diabetic patients.
AIM 03Evaluate the role of autophagic impairment in kidney injury susceptibility.
AIM 04Examine the impact of ER stress signaling on AKI severity in diabetes.
Skills the Lab Values
molecular biology techniquesmouse modelscell cultureprotein analysisimmunohistochemistryWestern blottingbiochemical assaysin vivo imagingRNA sequencing
Output against the department
Publications96bottom 33% of dept.689th of 1,033
this lab
most publishedleast published
Citations9.4ktop 41% of dept.419th of 1,033
this lab
most citedleast cited
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