University of Iowa · BiologyYang Cardiology Lab
Ling Yang · Iowa City, Iowa
Research Focus
Dr. Ling Yang's lab at the University of Iowa focuses on understanding how lysosomal dysfunction affects heart health, specifically in the context of heart failure with preserved ejection fraction (HFpEF). The lab uses innovative methods to study the role of lysosomes in controlling metabolic processes and inflammation in heart cells, aiming to uncover new therapeutic strategies for managing heart disease. Overall, the research will improve our understanding of the molecular mechanisms underlying cardiovascular health and disease.
heart failurelysosomescardiac metabolisminflammationimmuno-metabolic homeostasisGILTobesitymetabolic profilingcardiomyocytes
Research Aims
4AIM 01Investigate the pathological significance of GILT in heart failure with preserved ejection fraction.
AIM 02Elucidate mechanisms of GILT-regulated mitochondrial function in cardiomyocytes.
AIM 03Assess the impact of GILT on glucose homeostasis in heart cells.
AIM 04Explore the role of GILT in regulating inflammasome activation during cardiac stress.
Skills the Lab Values
mouse modelsmetabolomic analysescell culturemolecular biology techniquesprotein assaysRNA sequencingflow cytometryin vivo imagingdata analysis
Output against the department
Publications557top 6% of dept.61st of 1,033
this lab
most publishedleast published
Citations34ktop 9% of dept.94th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.