Drexel University · EngineeringAbrams Lab
Cameron F Abrams · Philadelphia, Pennsylvania
Research Focus
Dr. Cameron F. Abrams' lab at Drexel University focuses on understanding the conformational changes of the HIV-1 envelope glycoprotein (Env), which plays a critical role in how the virus enters human cells. By combining advanced molecular simulations with biophysical techniques, the lab aims to discover new ways to inhibit the virus and aid in vaccine development. This research is vital for creating effective treatments and vaccines for HIV.
HIV-1envelope glycoproteinmolecular dynamicsbiophysicsvaccine developmentviral entryconformational dynamicsantiviral inhibitorssingle-molecule FRET
Research Aims
5AIM 01Characterize the conformational dynamics of HIV-1 Env
AIM 02Identify critical structural changes between Env conformational states
AIM 03Incorporate biophysical data to refine molecular simulations
AIM 04Inform the design of immunogens and antiviral therapies
AIM 05Understand mechanisms of HIV-1 entry into cells
Skills the Lab Values
Molecular Dynamics (MD) simulationsSingle-molecule FRET (smFRET)Crosslinking mass spectrometry (XL-MS)Fluorescence spectroscopyProtein purificationData analysis using PythonStructural modelingBiophysical characterization techniquesExperiment design
Output against the department
Publications203top 47% of dept.130th of 278
this lab
most publishedleast published
Citations4.2kbottom 31% of dept.191st of 278
this lab
most citedleast cited
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