Princeton University · ChemistryProtein Manipulation and Engineering Lab
Tom Muir · Princeton, New Jersey
Research Focus
Dr. Tom Muir's research lab at Princeton University focuses on innovative protein manipulation techniques that utilize inteins, which are naturally occurring segments of proteins. The lab is engaged in developing tools for protein splicing that can reveal and modify complex biological systems, particularly in the context of epigenetics and chromatin biology. This research aims to enhance our understanding of disease processes and improve biotechnological applications.
inteinsprotein splicingepigeneticschromatin biologysynthetic biologyoncofusion proteinsbiochemical toolsprotein engineering
Research Aims
5AIM 01Develop split intein tools for incorporating chemical probes into target proteins.
AIM 02Create controllable inteins for use in basic science and synthetic biology.
AIM 03Investigate oncofusion proteins to understand early cell transformation.
AIM 04Design protein actuators to convert biochemical inputs into outputs.
AIM 05Utilize advanced protein trans-splicing techniques to study epigenetic regulation.
Skills the Lab Values
protein engineeringchemical biologycell culturebiochemical assaysprotein purificationgenetic cloningCRISPRmicroscopyRNA sequencing
Output against the department
Publications346top 31% of dept.68th of 216
this lab
most publishedleast published
Citations32ktop 12% of dept.27th of 216
this lab
most citedleast cited
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