UMCUniversity of Massachusetts Chan Medical School · Genetics
Ribosome Dynamics and Stress Response Unit
Andrei Korostelev · Worcester, Massachusetts
Research Focus
Dr. Andrei Korostelev's lab focuses on understanding ribosomes, the protein-synthesizing machinery in cells, and their regulatory roles in various biological processes. The research aims to uncover how ribosomes respond to cellular stress, influence neurodevelopment, and manage the production of proteins that are crucial for blood vessel growth. By employing advanced biophysical techniques, the lab seeks to elucidate the mechanisms behind these processes and their implications for treating diseases such as amyotrophic lateral sclerosis and cardiovascular issues.
ribosomestranslational controlangiogeningene expressionneurodevelopmentstress responsessynaptic plasticitybiochemical characterizationvisualization techniques
Research Aims
3AIM 01Investigate how ribosomes regulate stress responses in bacteria and their implications for antibiotic targets.
AIM 02Explore how ribosomes interact with dysfunctional mRNAs to understand their role in neurodevelopment and disease.
AIM 03Study the mechanisms through which angiogenin affects protein synthesis and blood vessel growth.
Skills the Lab Values
cryogenic electron microscopybiochemical assayscell culturemolecular cloningRNA analysisprotein purificationbiophysical methodsgenetic manipulationsequencing techniques
Output against the department
Publications1bottom 1% of dept.259th of 259
this lab
most publishedleast published
Citations2bottom 1% of dept.257th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.