Oregon Health & Science University · PhysiologyKidney Cell Dynamics Unit
David Hoadley Ellison · Portland, Oregon
Research Focus
The lab led by David Hoadley Ellison focuses on understanding the diverse cell types in the kidney, specifically in regions crucial for solute retention. By employing advanced techniques to analyze these cells in health and stress conditions, the research aims to unravel mechanisms that may lead to kidney dysfunction and related diseases. Students in this lab will learn about the unique roles of different kidney cell types and how they respond to dietary changes and drug treatments.
kidney physiologycell heterogeneitydistal convoluted tubulethick ascending limbdiuretic responsecell statepotassium stresscalcium reabsorptionhomeostasisimmunohistochemistry
Research Aims
5AIM 01Define cell types and states in the distal convoluted tubule and connecting tubule
AIM 02Characterize how potassium intake affects cell states
AIM 03Investigate how diuretics modify cell states and electrolyte excretion
AIM 04Characterize the cell types in the thick ascending limb of the kidney
AIM 05Examine the effects of water and calcium stress on kidney cell function.
Skills the Lab Values
cell cultureimmunohistochemistrytranscriptomic analysisanimal modelsphysiological modelinghistological techniquesdata visualizationgene expression analysispotassium and calcium assays
Output against the department
Publications435top 8% of dept.22nd of 286
this lab
most publishedleast published
Citations19ktop 15% of dept.44th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.