University of Michigan-Ann Arbor · NeuroscienceNeurogenetics and Disease Mechanisms Lab
Peter K Todd · Ann Arbor, Michigan
Research Focus
Dr. Peter K Todd's lab at the University of Michigan focuses on understanding the genetic causes of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). The lab investigates how a specific genetic mutation leads to the production of toxic proteins in neurons, potentially revealing new targets for therapeutic intervention. Their research combines cellular models, including patient-derived stem cells, to explore the mechanisms of disease and improve outcomes for affected individuals.
ALSFrontotemporal DementiaC9orf72RAN Translationneurotoxicity
Research Aims
5AIM 01Investigate the mRNA templates used for C9RAN translation in neurons.
AIM 02Determine the role of RNA structure in RAN translational efficiency.
AIM 03Explore the impact of ribosomal quality control on RAN translation.
AIM 04Identify potential therapeutic targets for ALS and FTD.
AIM 05Understand the mechanism of repeat expansion disorders.
Skills the Lab Values
cell cultureRNA sequencingmolecular cloningprotein purificationin vitro assays
Output against the department
Publications134bottom 47% of dept.354th of 671
this lab
most publishedleast published
Citations5.9kbottom 41% of dept.395th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.