University of Pennsylvania · BiologyXu Lab
Xiaowei Xu · Philadelphia, Pennsylvania
Research Focus
Dr. Xiaowei Xu's lab focuses on developing innovative therapies using advanced immunological approaches to combat melanoma, a serious skin cancer. The lab utilizes humanized mouse models to study immune responses and explore the potential of engineered immune cells and extracellular vesicles in targeted cancer therapies. Their research aims to make significant advancements in the effectiveness of existing cancer treatments while minimizing side effects.
gamma delta T cellsextracellular vesiclesmelanomaimmunotherapyadoptive cell therapycancer therapynatural killer cellspatient-derived xenograftstumor microenvironment
Research Aims
5AIM 01Develop humanized mouse models to test gamma-delta T cell therapies for melanoma.
AIM 02Engineer extracellular vesicles for targeted delivery of cancer therapies.
AIM 03Assess the efficacy of new immune cell expansion methods in vivo.
AIM 04Optimize the production and quality control of designer extracellular vesicles for clinical use.
AIM 05Evaluate combinatorial CAR strategies in melanoma treatment.
Skills the Lab Values
mouse modelsadoptive cell transfercancer cell cultureextracellular vesicle engineeringflow cytometryimmunophenotypingsiRNA deliveryviral vector designbioprocess optimizationtumor organoid cultures
Output against the department
Publications560top 6% of dept.58th of 1,033
this lab
most publishedleast published
Citations35ktop 9% of dept.89th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.