University of Virginia-Main Campus · BiologyWythe Vascular Lab
Joshua D. Wythe · Charlottesville, Virginia
Research Focus
Dr. Joshua D. Wythe's lab at the University of Virginia focuses on understanding brain arteriovenous malformations (bAVMs), which are dangerous blood vessel abnormalities that can lead to stroke, especially in children and young adults. The lab investigates the cellular and molecular mechanisms behind these conditions, particularly looking at genetic mutations and endothelial cell behavior. By using animal models, the team aims to find safer, drug-based treatments for these serious vascular issues.
brain arteriovenous malformationsendothelial biologyvascular pathologygene mutationscell cycle regulation
Research Aims
4AIM 01Investigate the dysregulation of cell cycle in the endothelium of bAVMs.
AIM 02Identify mechanisms driving progression of sporadic bAVMs.
AIM 03Determine if KRAS mutations serve as a second hit in inherited bAVM conditions.
AIM 04Explore potential pharmacological interventions targeting endothelial cell cycle dynamics.
Skills the Lab Values
animal modelsmolecular biology techniquescell cultureimaging techniquessingle-cell RNA sequencing
Output against the department
Publications92bottom 31% of dept.713th of 1,033
this lab
most publishedleast published
Citations6.0kbottom 43% of dept.589th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.