UCUniversity of Cincinnati-Main Campus · Pharmacology
Gao Lab
Chen Gao · Cincinnati, Ohio
Research Focus
Dr. Chen Gao's lab focuses on understanding how the degradation of RNA molecules influences the development of heart diseases, particularly heart hypertrophy. By studying the mechanisms of mRNA stability and degradation in heart cells, the lab aims to uncover new potential targets for treating cardiovascular diseases. Their research combines advanced sequencing technologies with mouse models to explore gene regulation in response to stress and other physiological changes.
cardiac hypertrophyRNA degradationmRNA stabilityheart diseasestress response
Research Aims
3AIM 01Establish the contribution of Upf1 in stress regulated mRNA degradation in cardiomyocytes.
AIM 02Determine the role of RBFox1c in target specificity for mRNA degradation.
AIM 03Investigate the functional significance of Upf1 mediated RNA degradation in cardiac hypertrophy.
Skills the Lab Values
RNA sequencingmouse modelsmRNA analysisimmunoprecipitationmolecular cloning
Output against the department
Publications248top 33% of dept.150th of 462
this lab
most publishedleast published
Citations7.1ktop 50% of dept.232nd of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.