University of Illinois Chicago · BiochemistryChronis Stem Cell Lab
Konstantinos Chronis · Chicago, Illinois
Research Focus
Dr. Konstantinos Chronis's lab focuses on how certain factors can transform cells found in blood vessels into hematopoietic stem cells (HSCs), which are vital for producing blood cells. By understanding this reprogramming process, the lab aims to develop new methods for generating HSCs that could be used in medical treatments. Their research explores the genetic changes that happen during this transformation and how to make the process more efficient and effective for clinical applications.
Hematopoietic Stem CellsCell ReprogrammingGene Regulatory NetworksEndothelial CellsTranscription FactorsSingle-Cell Multiomic ProfilingTransgenic Mouse ModelsMolecular MechanismsSignal Pathways
Research Aims
4AIM 01Investigate how reprogramming factors FGRS modulate gene regulatory networks in endothelial cells and HSCs.
AIM 02Dissect the intrinsic and extrinsic signaling pathways that facilitate the conversion of endothelial cells to HSCs.
AIM 03Understand the molecular mechanisms that lead to the heterogeneity of HSC populations during reprogramming.
AIM 04Explore the use of genetic factors to enhance the efficiency of HSC generation for therapeutic applications.
Skills the Lab Values
ATAC-seqSingle-cell RNA SequencingTransgenic Mouse GenerationCell Culture TechniquesMolecular CloningGene Expression AnalysisBioinformaticsFlow CytometryImmunofluorescence Microscopy
Output against the department
Publications2bottom 1% of dept.401st of 402
this lab
most publishedleast published
Citations138bottom 1% of dept.400th of 402
this lab
most citedleast cited
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