Princeton University · BiochemistryCell Fate and Differentiation Unit
Michelle Chan · Princeton, New Jersey
Research Focus
Dr. Michelle Chan's lab at Princeton University is focused on understanding how mammalian cells differentiate from pluripotent stem cells into specific cell types, like neurons or muscle. By creating comprehensive cell fate maps, her team aims to reveal the intricate pathways of differentiation, which might lead to advancements in cellular therapies for diseases such as Parkinson's and diabetes. The lab primarily employs innovative techniques like CRISPR genome editing and single-cell RNA sequencing to trace cell lineages and analyze the data computationally.
cell fate mappingdifferentiation pathwaysCRISPRsingle-cell RNA sequencinglineage tracingin vitro modelinggastruloidscomputational analysisstem cell therapy
Research Aims
5AIM 01Build comprehensive cell fate maps of mammalian development.
AIM 02Utilize CRISPR technology to trace cell lineages.
AIM 03Investigate differentiation pathways from pluripotency.
AIM 04Develop in vitro models using gastruloids for high-throughput studies.
AIM 05Identify genetic regulators for cell type manipulation.
Skills the Lab Values
CRISPR genome editingsingle-cell RNA sequencinglineage tracingcell culturemouse modelshidden Markov modelingbioinformaticsdata processingexperimental design
Output against the department
Publications55bottom 9% of dept.364th of 402
this lab
most publishedleast published
Citations3.8kbottom 20% of dept.323rd of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.