New York University · BiologyBoeke Lab
Jef D Boeke · New York, New York
Research Focus
Dr. Jef D Boeke's lab at NYU School of Medicine focuses on understanding how genes are regulated within our genomes. They create and manipulate large DNA constructs to study the effects of genetic elements on gene expression, with potential applications in gene therapy and biotechnology. The lab offers exciting opportunities for undergraduate students to be directly involved in these transformative research projects.
synthetic biologygene regulationgenome engineeringgene therapybiotechnologyhuman disease modelsCRISPRtranslational genomicsgenome assembly
Research Aims
4AIM 01Design and synthesize large DNA constructs to study gene regulation.
AIM 02Develop methods for integrating genetic constructs into genomes at specific locations.
AIM 03Investigate the effects of genetic elements on gene expression and chromatin structure.
AIM 04Create models to predict how genetic variations affect gene function.
Skills the Lab Values
DNA synthesisgene editinggenomic analysisstem cell techniquesmouse modelsPCRcell culturecomputational modelingchromatin assays
Output against the department
Publications591top 5% of dept.49th of 1,033
this lab
most publishedleast published
Citations64ktop 3% of dept.28th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.