University of Pennsylvania · PhysiologyJanmey Lab
Paul A Janmey · Philadelphia, Pennsylvania
Research Focus
Dr. Paul A. Janmey's lab at the University of Pennsylvania examines how the physical properties of cells and tissues influence their function and contribute to various diseases. The research focuses on the mechanical aspects of biopolymer networks, such as those found in the cytoskeleton and extracellular matrix, and their role in cell behavior. The lab also investigates the dynamics of the cell nucleus and how it responds to mechanical stress, which could provide insights into conditions like cancer and fibrotic diseases.
biopolymer networkscell mechanicsnuclear dynamicsviscoelasticityextracellular matrixcell phenotypechromatin remodelingmechanical stressbioengineering
Research Aims
5AIM 01Investigate the mechanical properties of biopolymer networks in tissues.
AIM 02Analyze the role of mechanical stress on cell nucleus function.
AIM 03Characterize the viscoelastic properties of cellular materials.
AIM 04Develop new biocompatible materials for studying cell mechanics.
AIM 05Explore the impact of extracellular matrix stiffness on cell behavior.
Skills the Lab Values
mechanical testingcell culturefluorescence microscopytissue engineeringdata modelingbiomechanicsprotein purification3D bioprintingATP assays
Output against the department
Publications612top 3% of dept.9th of 286
this lab
most publishedleast published
Citations60ktop 2% of dept.7th of 286
this lab
most citedleast cited
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