AECAlbert Einstein College of Medicine · Biochemistry
Cowburn Lab
David Cowburn · Bronx, New York
Research Focus
Dr. David Cowburn's lab at the Albert Einstein College of Medicine explores how the dynamic behaviors of disordered proteins influence their roles in various biological processes. By employing advanced techniques like NMR spectroscopy and molecular simulations, the lab is focusing on the nuclear pore complex and the engineering of proteins through inteins for therapeutic applications. This research is significant for understanding diseases like cancer and neurodegeneration, and may lead to new methods for targeted drug delivery.
nuclear pore complexprotein dynamicsprotein engineeringNMR spectroscopyinteinsbiomedical researchmolecular simulationstherapeuticsintrinsic disorder
Research Aims
5AIM 01Investigate the role of protein disorder in the nuclear pore complex.
AIM 02Map interactions of biomolecules and proteins through simulations.
AIM 03Engineer protein splicing techniques using inteins.
AIM 04Develop synthetic models for studying protein dynamics.
AIM 05Enhance understanding of disease mechanisms related to protein transport.
Skills the Lab Values
NMR spectroscopysmall angle scattering (SAS)molecular dynamics simulationsprotein purificationcryoelectron microscopyprotein engineeringDNA origami techniquescell cultureaffinity measurement
Output against the department
Publications328top 18% of dept.74th of 402
this lab
most publishedleast published
Citations13ktop 38% of dept.153rd of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.