University of Minnesota-Twin Cities · NeuroscienceNative American Dementia Research Lab
William G Mantyh · Minneapolis, Minnesota
Research Focus
Dr. William G Mantyh's lab focuses on understanding dementia, particularly Alzheimer's disease, in Native American communities. The lab is conducting important research to determine how genetic factors, like the APOE gene, affect dementia risk among Native Americans, an area that has been largely overlooked. By identifying the unique types of dementia that exist in these populations and how genetic ancestry influences risk, the lab aims to improve diagnosis and treatment outcomes for underserved communities.
Alzheimer's DiseasedementiaAPOE geneNative American healthbiomarkershealth disparitiespublic healthgenetic risk factorsblood testsbrain health
Research Aims
5AIM 01Identify the types of dementia prevalent among Native American Tribal Nations.
AIM 02Assess the impact of the APOE gene on Alzheimer's risk in Native Americans.
AIM 03Determine the effectiveness of blood tests for diagnosing Alzheimer's in Native American individuals.
AIM 04Investigate the unique dementia risk factors in the Native American population.
AIM 05Advance brain health policies based on the findings from the study.
Skills the Lab Values
blood test analysisgenetic sequencingepidemiological studiesdata analysisneuropsychological testingpublic health researchstatistical softwarebiomarker quantificationcommunity outreach
Output against the department
Publications49bottom 10% of dept.600th of 671
this lab
most publishedleast published
Citations2.0kbottom 13% of dept.586th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.