Columbia University in the City of New York · NeuroscienceTau and Synaptic Function Lab
Catarina M. Quinzii · New York, New York
Research Focus
Dr. Catarina M. Quinzii's lab at Columbia University focuses on understanding the molecular mechanisms behind frontotemporal dementia (FTD) caused by abnormal Tau protein. The lab investigates how a process called SUMOylation influences Tau behavior and its impact on brain function, specifically regarding mitochondria and synapses. By using animal models and cell lines derived from patients, the team aims to identify potential therapeutic strategies to improve cognitive functions in FTD.
Tau proteinfrontotemporal dementiaSUMOylationmitochondrial dysfunctionsynaptic function
Research Aims
3AIM 01Determine the relationship between SUMO conjugation and Tau-induced mitochondrial dysfunction.
AIM 02Test the impact of overexpressing SUMO1 on mitochondrial and synaptic function.
AIM 03Investigate whether increasing SUMO2 can rescue dysfunctions related to Tau in FTD models.
Skills the Lab Values
PCRcell cultureelectrophysiologybiochemical assaysanimal modelsbehavioral testingiPSC techniquesbiophysicsWestern blotdata analysis
Output against the department
Publications135bottom 48% of dept.351st of 671
this lab
most publishedleast published
Citations7.1kbottom 48% of dept.346th of 671
this lab
most citedleast cited
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