Ohio State University-Main Campus · PharmacologyPolypharmacy Risk Lab
Macarius M. Donneyong · Columbus, Ohio
Research Focus
Dr. Macarius M. Donneyong's lab at Ohio State University focuses on understanding the risks associated with using multiple medications (polypharmacy) in older adults, particularly those aged 65 and over. The lab aims to identify specific combinations of three drugs that could lead to serious adverse drug events (ADEs) like gastrointestinal bleeding, hypoglycemia, and opioid-related complications, which are common reasons for emergency department visits. By using advanced data mining and pharmacoepidemiological methods, the lab works to improve drug safety recommendations for older patients.
polypharmacyadverse drug eventsdrug interactionspharmacoepidemiologyemergency departmentolder adultsrisk assessmentdata miningcomparative safety
Research Aims
3AIM 01Identify high-order drug interactions associated with increased risk of adverse drug events.
AIM 02Assess the comparative safety of specific 3-drug combinations in older adults.
AIM 03Validate and evaluate clinical mechanisms associated with high-risk drug combinations.
Skills the Lab Values
data miningpharmacoepidemiologyElectronic Health Records (EHR) analysisstatistical modelingclinical data interpretationcomparative safety assessmentdrug interaction analysishealth insurance claims analysismixed drug-count response modeling
Output against the department
Publications101bottom 25% of dept.344th of 462
this lab
most publishedleast published
Citations1.0kbottom 4% of dept.442nd of 462
this lab
most citedleast cited
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