Johns Hopkins University · BiologyMetastasis Mapping Lab
Andrew Josef Ewald · Baltimore, Maryland
Research Focus
Dr. Andrew Josef Ewald's lab at Johns Hopkins University studies how cancer cells change and behave as they spread from one part of the body to another. They use cutting-edge techniques, including single-cell sequencing and machine learning, to map these changes and understand the processes driving metastasis in breast cancer. The lab aims to identify potential new targets for treatments that could stop cancer from spreading and improve patient outcomes.
metastasisbreast cancersingle-cell sequencingmachine learningdifferentiation3D cultureepithelial morphogenesisgene regulatory programsspatial transcriptomicscell state mapping
Research Aims
3AIM 01Map the cell state transitions in breast cancer during metastasis.
AIM 02Model the dynamics of differentiation in cancer progression.
AIM 03Identify and validate genes that regulate metastatic transitions in vitro and in vivo.
Skills the Lab Values
single-cell RNA sequencing (scRNA-seq)3D culture systemsmachine learning algorithmsspatial transcriptomicsdata analysis in R/Pythongenetic assaystumor modeling in micedifferential gene expression analysiscell culture techniquesbiological modeling
Output against the department
Publications295top 19% of dept.197th of 1,033
this lab
most publishedleast published
Citations18ktop 21% of dept.218th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.