Oregon Health & Science University · BiologyVascular Health and Cognitive Function Lab
Yabing Chen · Portland, Oregon
Research Focus
Dr. Yabing Chen's research lab at Oregon Health & Science University focuses on understanding the links between vascular health and cognitive function, particularly in age-related conditions like vascular dementia and Alzheimer's disease. The lab investigates how specific proteins influence the behavior of vascular cells and how these changes can lead to broader implications for cardiovascular disease and dementia. By exploring genetic and molecular mechanisms, the research aims to develop better treatment strategies for these conditions.
vascular dementiaAlzheimer's diseasevascular calcificationvascular smooth muscle cellsRunx2PRMT1cardiovascular diseasesdementiasmooth muscle cell phenotypic switchmolecular signaling
Research Aims
5AIM 01Investigate the role of Runx2 in vascular dysfunction and cognitive impairment.
AIM 02Explore the mechanisms of vascular smooth muscle cell phenotypic modulation and calcification.
AIM 03Determine the function of PRMT1 in regulating Runx2 in vascular diseases.
AIM 04Identify genetic risk factors linked to vascular dementia and Alzheimer's disease.
AIM 05Develop novel treatment strategies to improve vascular health and cognitive function.
Skills the Lab Values
single cell RNA sequencing (scRNA-seq)animal modelsvascular smooth muscle cell culturebiochemical assaysproteomics analysisbioinformaticsgene expression analysismolecular cloningWestern blottingdata analysis using Python
Output against the department
Publications100bottom 35% of dept.670th of 1,033
this lab
most publishedleast published
Citations3.5kbottom 26% of dept.762nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.