University of Michigan-Ann Arbor · Biomedical EngineeringShea Biomedical Lab
Lonnie D Shea · Ann Arbor, Michigan
Research Focus
Dr. Lonnie D. Shea's lab at the University of Michigan focuses on advanced biomedical engineering techniques to tackle major health issues like type 1 diabetes and breast cancer. The research includes developing improved pancreatic organoids and engineered scaffolds to enhance the effectiveness of cell transplants and monitor cancer progression. They aim to use innovative materials, such as nanoparticles and 3D scaffolding technologies, to improve therapeutic responses and patient outcomes.
type 1 diabetesislet organoidsbiomedical engineeringcancer immunotherapynanoparticlescell transplantationmetabolic maturityimmune responsetissue scaffoldingdrug delivery
Research Aims
5AIM 01Enhance metabolic maturity of islet organoids for better transplantation outcomes.
AIM 02Develop scaffolds to monitor immune response and disease recurrence in cancer patients.
AIM 03Investigate use of nanoparticles to reprogram immune cells and combat tumor metastasis.
AIM 04Create biodegradable particles to promote immune tolerance in food allergies.
AIM 05Use engineered scaffolds to analyze and predict responses to therapies in cancer treatment.
Skills the Lab Values
3D culture techniquescellular engineeringstem cell differentiationmicroscopyRNA analysisanimal modelsnanoparticle synthesisbiochemical assaysimmune cell profilingdata modeling
Output against the department
Publications299top 31% of dept.185th of 595
this lab
most publishedleast published
Citations15ktop 24% of dept.144th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.