University of North Carolina at Chapel Hill · GeneticsMohlke Lab
Karen L. Mohlke · Chapel Hill, North Carolina
Research Focus
Dr. Mohlke's lab focuses on understanding the genetic underpinnings of type 2 diabetes (T2D) and related metabolic traits. By conducting extensive genetic analysis, they aim to identify the specific genes and variants that contribute to these conditions, particularly their effects at the cellular level in tissues such as the liver and adipose tissue. This research holds great potential for uncovering new therapeutic targets and improving disease prediction and treatment.
type 2 diabetesgenetic analysisGWASmetabolic traitsregulatory variantsgene expressionliver metabolismadipose tissuefunctional genomics
Research Aims
5AIM 01Identify genetic variants associated with type 2 diabetes and metabolic traits.
AIM 02Characterize the role of liver and adipose tissue in metabolic regulation.
AIM 03Investigate the cellular mechanisms through which genetic variants influence gene expression.
AIM 04Validate the functional impact of identified variants on gene expression and metabolic traits.
AIM 05Develop insights that could lead to new therapeutic strategies for diabetes.
Skills the Lab Values
genome-wide association studies (GWAS)single nucleus RNA sequencingchromatin accessibility assayshigh-throughput transcriptional assaysgenome editingcell culture techniquesRNA extraction and analysistranscriptional reporter assaysdata integration and analysis
Output against the department
Publications561top 10% of dept.27th of 259
this lab
most publishedleast published
Citations81ktop 7% of dept.17th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.